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Infliximab enhances the therapeutic effectiveness of octreotide on acute necrotizing pancreatitis in rat model.
- Source :
-
Pancreas [Pancreas] 2012 Aug; Vol. 41 (6), pp. 849-54. - Publication Year :
- 2012
-
Abstract
- Objectives: To investigate the synergistic activity of infliximab to the therapeutic effectiveness of octreotide in a rat model of acute necrotizing pancreatitis (ANP).<br />Methods: Forty Sprague-Dawley rats were randomly divided into sham-operated group (SO), ANP group (ANP), octreotide group (OG), infliximab group (IG), and combination group (CG) (n = 8 in each group). The ANP model was induced by biliopancreatic duct injection with 4.5% of sodium taurocholate solution. Rats of the OG, IG, and CG were given a tail vein injection of octreotide (10 μg/kg), infliximab (8 mg/kg), and infliximab (8 mg/kg), respectively, combined with octreotide (10 μg/kg) at 6 hours after modeling. All rats in each group were killed at 24 hours after modeling. Serum biochemical indicator and partial pressure of arterial oxygen/fraction of inspired oxygen (PaO2/FiO2) of rats were determined. Pathological severity score of organs were evaluated.<br />Results: The serum biochemical indicator and organs' pathology score of OG , IG, and CG were obviously lower than those in the ANP group, and those in the CG were the lowest (P < 0.05). The PaO2/FiO2 levels in the OG, IG, and CG were significantly higher than that in the ANP group (P < 0.05).<br />Conclusion: Infliximab could significantly lower the serum biochemical indicator, improve organs' function, and enhance the therapeutic effectiveness of octreotide on ANP.
- Subjects :
- Animals
Antibodies, Monoclonal administration & dosage
Biomarkers blood
Disease Models, Animal
Drug Synergism
Drug Therapy, Combination
Female
Infliximab
Injections, Intravenous
Liver Failure etiology
Liver Failure prevention & control
Multiple Organ Failure etiology
Multiple Organ Failure pathology
Octreotide administration & dosage
Pancreatitis, Acute Necrotizing blood
Pancreatitis, Acute Necrotizing chemically induced
Pancreatitis, Acute Necrotizing complications
Pancreatitis, Acute Necrotizing pathology
Protective Agents administration & dosage
Rats
Rats, Sprague-Dawley
Renal Insufficiency etiology
Renal Insufficiency prevention & control
Respiratory Insufficiency etiology
Respiratory Insufficiency prevention & control
Severity of Illness Index
Taurocholic Acid
Time Factors
Antibodies, Monoclonal pharmacology
Multiple Organ Failure prevention & control
Octreotide pharmacology
Pancreatitis, Acute Necrotizing drug therapy
Protective Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4828
- Volume :
- 41
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Pancreas
- Publication Type :
- Academic Journal
- Accession number :
- 22450369
- Full Text :
- https://doi.org/10.1097/MPA.0b013e31823fbdc3