Back to Search
Start Over
The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.
- Source :
-
The Journal of experimental medicine [J Exp Med] 2012 Apr 09; Vol. 209 (4), pp. 837-54. Date of Electronic Publication: 2012 Apr 02. - Publication Year :
- 2012
-
Abstract
- Parkinson's disease (PD) is a progressive, chronic disease characterized by dyskinesia, rigidity, instability, and tremors. The disease is defined by the presence of Lewy bodies, which primarily consist of aggregated α-synuclein protein, and is accompanied by the loss of monoaminergic neurons. Current therapeutic strategies only give symptomatic relief of motor impairment and do not address the underlying neurodegeneration. Hence, we have identified Cu(II)(atsm) as a potential therapeutic for PD. Drug administration to four different animal models of PD resulted in improved motor and cognition function, rescued nigral cell loss, and improved dopamine metabolism. In vitro, this compound is able to inhibit the effects of peroxynitrite-driven toxicity, including the formation of nitrated α-synuclein oligomers. Our results show that Cu(II)(atsm) is effective in reversing parkinsonian defects in animal models and has the potential to be a successful treatment of PD.
- Subjects :
- Animals
Cell Line, Tumor
Coordination Complexes
Disease Models, Animal
Humans
Male
Mice
Mice, Inbred C57BL
Molsidomine analogs & derivatives
Molsidomine pharmacology
Neuroprotective Agents pharmacology
Organometallic Compounds pharmacology
Parkinson Disease psychology
Positron-Emission Tomography
Radiopharmaceuticals pharmacology
Rats
Rats, Sprague-Dawley
Thiosemicarbazones pharmacology
alpha-Synuclein chemistry
Cognition drug effects
Motor Activity drug effects
Neuroprotective Agents therapeutic use
Organometallic Compounds therapeutic use
Parkinson Disease drug therapy
Radiopharmaceuticals therapeutic use
Thiosemicarbazones therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1540-9538
- Volume :
- 209
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 22473957
- Full Text :
- https://doi.org/10.1084/jem.20112285