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Final results of a multicenter phase II clinical trial evaluating the activity of single-agent lapatinib in patients with HER2-negative metastatic breast cancer and HER2-positive circulating tumor cells. A proof-of-concept study.
- Source :
-
Breast cancer research and treatment [Breast Cancer Res Treat] 2012 Jul; Vol. 134 (1), pp. 283-9. Date of Electronic Publication: 2012 Apr 04. - Publication Year :
- 2012
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Abstract
- This multicenter phase II trial was designed to evaluate the activity of lapatinib in metastatic breast cancer patients with HER2-negative primary tumors and HER2-positive circulating tumor cells (CTCs). In this study MBC patients with HER2-negative primary tumors and HER2-positive CTCs previously treated with at least a first-line therapy for metastatic disease received lapatinib 1500 mg/day. The CellSearch System® was used for CTCs isolation and bio-characterization. HER2 status was assessed on CTCs by immunofluorescence. A case was defined as CTCs positive if ≥2 CTC/7.5 ml of blood were isolated and HER2-positive if ≥50% of CTCs were HER2-positive. 139 HER2-negative patients were screened, 96 patients were positive for CTCs (mean number of CTCs: 85; median number of CTCs: 19; range 2-1637). Seven of the 96 patients (7%) had ≥50% HER2-positive CTCs and were eligible for treatment with lapatinib. No objective tumor responses occurred in this population. In one patient, disease stabilization lasting 254 days (8.5 months) was observed. From the findings of this study, we concluded that a subset of patients with a HER2-negative primary tumor presents HER2-positive CTCs during disease progression, although the HER2 shift rate seems to be lower than previously reported. Despite the lack of objective response, the durable disease stabilization observed in one patient cannot rule out the hypothesis that lapatinib may have some activity in this patient population. However, considering that only 1/139 screened patients may potentially have derived benefit from this approach, future trials designed according to the presented strategy cannot be recommended.
- Subjects :
- Antineoplastic Agents pharmacology
Breast Neoplasms metabolism
Breast Neoplasms pathology
Carcinoma, Ductal, Breast metabolism
Carcinoma, Ductal, Breast secondary
Carcinoma, Lobular metabolism
Carcinoma, Lobular secondary
Female
Humans
Lapatinib
Middle Aged
Quinazolines pharmacology
Treatment Outcome
Antineoplastic Agents therapeutic use
Breast Neoplasms drug therapy
Carcinoma, Ductal, Breast drug therapy
Carcinoma, Lobular drug therapy
Neoplastic Cells, Circulating metabolism
Quinazolines therapeutic use
Receptor, ErbB-2 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7217
- Volume :
- 134
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Breast cancer research and treatment
- Publication Type :
- Academic Journal
- Accession number :
- 22476856
- Full Text :
- https://doi.org/10.1007/s10549-012-2045-1