Comparison of total laryngectomy with surgical (cricohyoidopexy) and nonsurgical organ-preservation modalities in advanced laryngeal squamous cell carcinomas: A multicenter retrospective analysis.

Authors :: Bussu F
Paludetti G
Almadori G
De Virgilio A
Galli J
Miccichè F
Tombolini M
Rizzo D
Gallo A
Giglia V
Greco A
Valentini V
De Vincentiis M
Source :: Head & neck [Head Neck] 2013 Apr; Vol. 35 (4), pp. 554-61. Date of Electronic Publication: 2012 Apr 12.
Publication Year :: 2013
Abstract: Background: Functional outcome and quality of life (QOL) have become relevant endpoints in the field of laryngeal oncology, leading to the emergence of organ-preserving strategies.<br />Methods: The medical records of 166 patients with advanced (stages III and IV) laryngeal squamous cell carcinoma (SCC) who were treated with a total laryngectomy, radiochemotherapy, or cricohyoidopexy (CHP) were reviewed.<br />Results: In the whole series, no statistically significant differences among the 3 treatment arms with respect to the overall survival (OS) and disease-specific survival (DSS) rates were observed. The organ-preservation rate was 45% for radiotherapy and 76.7% for CHP (p = .0002). Among the cT4a cases, a longer survival was observed for the patients treated with total laryngectomy (3 yr-OS = 78% vs 68% for CHP and 54% for radiochemotherapy, p = .031).<br />Conclusions: In advanced laryngeal SCC, CHP shows survival rates comparable to those of radiochemotherapy and a higher larynx-preservation rate, although it may not replace radiochemotherapy because it can be recommended only in selected cases.<br /> (Copyright © 2012 Wiley Periodicals, Inc.)

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