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[A case of locally advanced rectal cancer had a pathological complete response to XELOX Therapy].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2012 Apr; Vol. 39 (4), pp. 683-6. - Publication Year :
- 2012
-
Abstract
- The patient was a 62-year-old man with bowel obstruction in a locally advanced rectal cancer. Computed tomography (CT) scan of the abdomen showed tumor enlargement(11.4 × 9.0 cm)that invaded the urinary bladder, but no distant metastasis. XELOX therapy was planned in order to shrink or eliminate the tumor after a sigmoid colostomy. Four courses of XELOX therapy were perfomed. Consequently, the level of the tumor marker had been restored to a normal range. CT scan revealed marked shrinkage of the tumor (6.1 × 5.2 cm) and a sharply-defined border between the tumor and the urinary bladder. Three weeks after chemotherapy, a low anterior resection as a radical surgery, and a temporary ileostomy were performed. The post-operative course was good. The histological effect was judged to be grade 3. There were no viable cancer cells in the rectal tumor and lymph nodes. The patient is alive and has been disease-free for 10 months after the operation. XELOX therapy as pre-operative chemotherapy might be safe and effective for patients with locally advanced rectal cancer.
- Subjects :
- Capecitabine
Carcinoembryonic Antigen blood
Deoxycytidine analogs & derivatives
Deoxycytidine therapeutic use
Fluorouracil analogs & derivatives
Fluorouracil therapeutic use
Humans
Male
Middle Aged
Oxaloacetates
Rectal Neoplasms blood
Rectal Neoplasms pathology
Rectal Neoplasms surgery
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Rectal Neoplasms drug therapy
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 39
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 22504703