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Associations between XPD Asp312Asn polymorphism and risk of head and neck cancer: a meta-analysis based on 7,122 subjects.
- Source :
-
PloS one [PLoS One] 2012; Vol. 7 (4), pp. e35220. Date of Electronic Publication: 2012 Apr 20. - Publication Year :
- 2012
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Abstract
- Background: To investigate the association between XPD Asp312Asn polymorphism and head and neck cancer risk through this meta-analysis.<br />Methods: We performed a meta-analysis of 9 published case-control studies including 2,670 patients with head and neck cancer and 4,452 controls. An odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the association between XPD Asp312Asn polymorphism and head and neck cancer risk.<br />Results: Overall, no significant association between XPD Asp312Asn polymorphism and head and neck cancer risk was found in this meta-analysis (Asn/Asn vs. Asp/Asp: OR = 0.95, 95%CI = 0.80-1.13, P = 0.550, P(heterogeneity) = 0.126; Asp/Asn vs. Asp/Asp: OR = 1.11, 95%CI = 0.99-1.24, P = 0.065, P(heterogeneity) = 0.663; Asn/Asn+Asp/Asn vs. Asp/Asp: OR = 1.07, 95%CI = 0.97-1.19, P = 0.189, P(heterogeneity) = 0.627; Asn/Asn vs. Asp/Asp+Asp/Asn: OR = 0.87, 95%CI = 0.68-1.10, P = 0.243, P(heterogeneity) = 0.089). In the subgroup analysis by HWE, ethnicity, and study design, there was still no significant association detected in all genetic models.<br />Conclusions: This meta-analysis demonstrates that XPD Asp312Asn polymorphism may not be a risk factor for developing head and neck cancer.
- Subjects :
- Asian People
Case-Control Studies
Genetic Association Studies
Genetic Predisposition to Disease
Head and Neck Neoplasms ethnology
Humans
Odds Ratio
Risk Factors
White People
Amino Acid Substitution
Head and Neck Neoplasms genetics
Polymorphism, Single Nucleotide
Xeroderma Pigmentosum Group D Protein genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 7
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 22536360
- Full Text :
- https://doi.org/10.1371/journal.pone.0035220