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Rare protein sequence variation in SV2A gene does not affect response to levetiracetam.
- Source :
-
Epilepsy research [Epilepsy Res] 2012 Sep; Vol. 101 (3), pp. 277-9. Date of Electronic Publication: 2012 Apr 30. - Publication Year :
- 2012
-
Abstract
- Levetiracetam, a broad spectrum antiepileptic drug, binds to membrane protein SV2A. The protein coding region of SV2A was sequenced in 158 patients with focal or generalized epilepsies divided into three groups based on their response to levetiracetam: responders (>75% decrease), exacerbators (50% increase) and non-responders. Nonsynonymous coding variation within SV2A was extremely rare, suggesting that rare variation is not likely to account for the individual differences in response to levetiracetam.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Child
Child, Preschool
Female
Genetic Variation
Humans
Levetiracetam
Male
Middle Aged
Pharmacogenetics
Piracetam therapeutic use
Anticonvulsants therapeutic use
Epilepsy drug therapy
Epilepsy genetics
Membrane Glycoproteins genetics
Nerve Tissue Proteins genetics
Piracetam analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1872-6844
- Volume :
- 101
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Epilepsy research
- Publication Type :
- Academic Journal
- Accession number :
- 22551666
- Full Text :
- https://doi.org/10.1016/j.eplepsyres.2012.04.007