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Merging of the National Cancer Institute-funded cooperative oncology group data with an administrative data source to develop a more effective platform for clinical trial analysis and comparative effectiveness research: a report from the Children's Oncology Group.
- Source :
-
Pharmacoepidemiology and drug safety [Pharmacoepidemiol Drug Saf] 2012 May; Vol. 21 Suppl 2, pp. 37-43. - Publication Year :
- 2012
-
Abstract
- Purpose: The National Cancer Institute-funded cooperative oncology group trials have improved overall survival for children with cancer from 10% to 85% and have set standards of care for adults with malignancies. Despite these successes, cooperative oncology groups currently face substantial challenges. We are working to develop methods to improve the efficiency and effectiveness of these trials. Specifically, we merged data from the Children's Oncology Group (COG) and the Pediatric Health Information Systems (PHIS) to improve toxicity monitoring, to estimate treatment-associated resource utilization and costs, and to address important clinical epidemiology questions.<br />Methods: COG and PHIS data on patients enrolled on a phase III COG trial for de novo acute myeloid leukemia at 43 PHIS hospitals were merged using a probabilistic algorithm. Resource utilization summary statistics were then tabulated for the first chemotherapy course based on PHIS data.<br />Results: Of 416 patients enrolled on the phase III COG trial at PHIS centers, 392 (94%) were successfully matched. Of these, 378 (96%) had inpatient PHIS data available beginning at the date of study enrollment. For these, daily blood product usage and anti-infective exposures were tabulated and standardized costs were described.<br />Conclusions: These data demonstrate that patients enrolled in a cooperative group oncology trial can be successfully identified in an administrative data set and that supportive care resource utilization can be described. Further work is required to optimize the merging algorithm, map resource utilization metrics to the National Cancer Institute Common Toxicity Criteria for monitoring toxicity, to perform comparative effectiveness studies, and to estimate the costs associated with protocol therapy.<br /> (Copyright © 2012 John Wiley & Sons, Ltd.)
- Subjects :
- Adolescent
Child
Child, Preschool
Cooperative Behavior
Costs and Cost Analysis
Female
Hospitals, Pediatric
Humans
Infant
Male
Medical Oncology economics
Medical Oncology organization & administration
Medical Oncology standards
Medical Oncology statistics & numerical data
Medical Records Systems, Computerized economics
Medical Records Systems, Computerized standards
Medical Records Systems, Computerized statistics & numerical data
National Cancer Institute (U.S.)
Organizational Objectives
Outcome and Process Assessment, Health Care
United States
Young Adult
Child Health Services economics
Child Health Services standards
Child Health Services statistics & numerical data
Clinical Trials, Phase III as Topic economics
Clinical Trials, Phase III as Topic standards
Clinical Trials, Phase III as Topic statistics & numerical data
Comparative Effectiveness Research
Medical Oncology trends
Medical Record Linkage
Medical Records Systems, Computerized trends
Neoplasms economics
Neoplasms mortality
Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1099-1557
- Volume :
- 21 Suppl 2
- Database :
- MEDLINE
- Journal :
- Pharmacoepidemiology and drug safety
- Publication Type :
- Academic Journal
- Accession number :
- 22552978
- Full Text :
- https://doi.org/10.1002/pds.3241