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PDGFBB promotes PDGFRα-positive cell migration into artificial bone in vivo.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2012 May 18; Vol. 421 (4), pp. 785-9. Date of Electronic Publication: 2012 Apr 23. - Publication Year :
- 2012
-
Abstract
- Bone defects caused by traumatic bone loss or tumor dissection are now treated with auto- or allo-bone graft, and also occasionally by artificial bone transplantation, particularly in the case of large bone defects. However, artificial bones often exhibit poor affinity to host bones followed by bony union failure. Thus therapies combining artificial bones with growth factors have been sought. Here we report that platelet derived growth factor bb (PDGFBB) promotes a significant increase in migration of PDGF receptor α (PDGFRα)-positive mesenchymal stem cells/pre-osteoblastic cells into artificial bone in vivo. Growth factors such as transforming growth factor beta (TGFβ) and hepatocyte growth factor (HGF) reportedly inhibit osteoblast differentiation; however, PDGFBB did not exhibit such inhibitory effects and in fact stimulated osteoblast differentiation in vitro, suggesting that combining artificial bones with PDGFBB treatment could promote host cell migration into artificial bones without inhibiting osteoblastogenesis.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Becaplermin
Cell Movement physiology
Cell Proliferation drug effects
Extracellular Signal-Regulated MAP Kinases metabolism
Humans
Mesenchymal Stem Cells metabolism
Mesenchymal Stem Cells physiology
Mice
Osteoblasts cytology
Osteoblasts enzymology
Bone and Bones cytology
Cell Movement drug effects
Mesenchymal Stem Cells drug effects
Proto-Oncogene Proteins c-sis pharmacology
Receptor, Platelet-Derived Growth Factor alpha metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 421
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 22554514
- Full Text :
- https://doi.org/10.1016/j.bbrc.2012.04.084