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Serum insulin-like growth factor-I (IGF-I) reference ranges for chemiluminescence assay in childhood and adolescence. Data from a population of in- and out-patients.
- Source :
-
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society [Growth Horm IGF Res] 2012 Jun-Aug; Vol. 22 (3-4), pp. 134-8. Date of Electronic Publication: 2012 May 14. - Publication Year :
- 2012
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Abstract
- Background: Insulin-like growth factor I (IGF-I) measurement is widely used for the diagnosis of disorders of GH secretion and sensitivity, and for monitoring of both GH and IGF-I replacement therapies. However, the lack of appropriate reference values obtained from large and representative samples undermines its practical utility.<br />Objective: To establish IGF-I reference values for a commonly used enzyme-labeled chemiluminescent immunometric assay in a large population of children aged 0 to 18 years.<br />Design: Cross-sectional analysis of serum IGF-I levels from samples collected in the two major Italian Children's Hospitals.<br />Subjects and Methods: IGF-I was measured using a solid-phase, enzyme-labeled chemiluminescent immunometric assay in 24403 children (50.6% girls) aged 0 to 18 years. Quantile regression coupled to multivariable fractional polynomials was used to produce age- and sex-specific reference values.<br />Main Outcome Measure: Age- and sex-specific IGF-I reference values.<br />Results and Conclusion: Reference values for immunometric assay of IGF-I were produced in a large sample of children and adolescents. Prediction equations were provided to automatize their calculations.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1532-2238
- Volume :
- 22
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
- Publication Type :
- Academic Journal
- Accession number :
- 22583946
- Full Text :
- https://doi.org/10.1016/j.ghir.2012.04.005