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Visible and near-infrared spectra collected from the thumbs of patients with chronic fatigue syndrome for diagnosis.
- Source :
-
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2012 Oct 09; Vol. 413 (19-20), pp. 1629-32. Date of Electronic Publication: 2012 May 11. - Publication Year :
- 2012
-
Abstract
- Background: Currently, diagnosis of chronic fatigue syndrome (CFS) is based on clinical symptoms and therefore relies on the experience and skill of the doctors. Here, we have examined the possible diagnosis of CFS based on spectral information and chemometrics analysis, such as principal component analysis (PCA) and soft modeling of class analogy (SIMCA).<br />Methods: Visible and near-infrared (Vis-NIR) spectroscopy was used to examine possible changes in the region of 600-1100 nm in thumbs and assessed.<br />Results: The Vis-NIR spectra of thumbs from 57 CFS patients and 74 healthy volunteers were subjected to PCA and SIMCA to develop multivariate models to discriminate between CFS patients and healthy individuals. The model was further assessed by the prediction of 120 determinations (60 in the healthy group and 60 in the CFS patient group). The PCA model predicted a discrimination of the masked samples; specifically the SIMCA model correctly predicted 51 of 60 (83.3%) healthy volunteers and 42 of 60 (70%) CFS patients.<br />Conclusions: Despite the relatively small number of subjects involved in this trial, who were exclusively Japanese, our results imply that Vis-NIR spectroscopy of the thumb combined with chemometrics analysis may provide a valuable tool for diagnosing CFS.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Asian People
Case-Control Studies
Electronic Data Processing
Female
Humans
Light
Male
Middle Aged
Predictive Value of Tests
Principal Component Analysis
Spectroscopy, Near-Infrared instrumentation
Spectroscopy, Near-Infrared methods
Spectrum Analysis instrumentation
Spectrum Analysis methods
Fatigue Syndrome, Chronic diagnosis
Thumb physiology
Thumb physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3492
- Volume :
- 413
- Issue :
- 19-20
- Database :
- MEDLINE
- Journal :
- Clinica chimica acta; international journal of clinical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 22583968
- Full Text :
- https://doi.org/10.1016/j.cca.2012.05.004