[Estimate of aztreonam (AZT) hydrolyzing enzymes from clinically isolated AZT-resistant gram-negative bacilli].

Authors :: Kouda M
Kumagai I
Kobayashi J
Sugai R
Matsuzaki H
Nakaya R
Source :: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases [Kansenshogaku Zasshi] 1990 Oct; Vol. 64 (10), pp. 1345-54.
Publication Year :: 1990
Abstract: The MICs of Aztreonam (AZT) against 590 clinical isolates of Gram-negative bacilli were determined. About 13.4% (79 strains) of the isolates were AZT-resistant (MIC; 12.5 micrograms/ml less than or equal to). The resistance pattern against various beta-lactams and the effects on MICs of combination of Clavulanic acid (CVA) and AZT against AZT resistant strains suggested that AZT was inactivated by either type of IV (K1), Va (OXA1), or PSE2 beta-lactamases.

Subjects :: Aztreonam pharmacology
Bacillus drug effects
Drug Resistance
Humans
Hydrolysis
Aztreonam metabolism
Bacillus enzymology
beta-Lactamases metabolism

Language :: Japanese
ISSN :: 0387-5911
Volume :: 64
Issue :: 10
Database :: MEDLINE
Journal :: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Publication Type :: Academic Journal
Accession number :: 2258651
Full Text :: https://doi.org/10.11150/kansenshogakuzasshi1970.64.1345

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