Plasma separation by centrifugation and subsequent plasma filtration: impact on survival in a pig model of sepsis.

Authors :: Sauer M
Altrichter J
Mencke T
Klöhr S
Thomsen M
Kreutzer HJ
Nöldge-Schomburg G
Mitzner SR
Source :: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy [Ther Apher Dial] 2012 Jun; Vol. 16 (3), pp. 205-12. Date of Electronic Publication: 2012 Mar 05.
Publication Year :: 2012
Abstract: The impact on survival of a combination of plasma separation by centrifugation and subsequent plasma filtration was tested in a bacterial sepsis model in pigs. In this animal study 19 pigs were included. Groups II and III received an intravenous lethal dose of live Staphylococcus aureus over 1 h; group I received saline (non-septic control--NC). Groups I and II were treated by an extracorporeal circuit consisting of online centrifugation and subsequent plasma filtration (group II: treated group--TG) for 4 h; group III had no specific treatment (septic control, SC). The observation time was 7 days. All animals of group I (NC) and group II (TG) survived, while all animals of group III (SC) died during the observation time. Extracorporeal therapy with online centrifugation and plasma filtration significantly improved survival in a pig model of sepsis. Further studies with this approach are encouraged.<br /> (© 2012 The Authors. Therapeutic Apheresis and Dialysis © 2012 International Society for Apheresis.)

Language :: English
ISSN :: 1744-9987
Volume :: 16
Issue :: 3
Database :: MEDLINE
Journal :: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Publication Type :: Academic Journal
Accession number :: 22607562
Full Text :: https://doi.org/10.1111/j.1744-9987.2011.01055.x

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