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A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies.

Authors :
Doria-Rose NA
Georgiev I
O'Dell S
Chuang GY
Staupe RP
McLellan JS
Gorman J
Pancera M
Bonsignori M
Haynes BF
Burton DR
Koff WC
Kwong PD
Mascola JR
Source :
Journal of virology [J Virol] 2012 Aug; Vol. 86 (15), pp. 8319-23. Date of Electronic Publication: 2012 May 23.
Publication Year :
2012

Abstract

Antibody PG9 is a prototypical member of a class of V1/V2-directed antibodies that effectively neutralizes diverse strains of HIV-1. We analyzed strain-specific resistance to PG9 using sequence and structural information. For multiply resistant strains, mutations in a short segment of V1/V2 resulted in gain of sensitivity to PG9 and related V1/V2 neutralizing antibodies, suggesting both a common mechanism of HIV-1 resistance to and a common mode of recognition by this class of antibodies.

Details

Language :
English
ISSN :
1098-5514
Volume :
86
Issue :
15
Database :
MEDLINE
Journal :
Journal of virology
Publication Type :
Academic Journal
Accession number :
22623764
Full Text :
https://doi.org/10.1128/JVI.00696-12