Back to Search
Start Over
[Neuroprotective and cardioprotective effects of hypothermic preconditioning].
- Source :
-
Patologicheskaia fiziologiia i eksperimental'naia terapiia [Patol Fiziol Eksp Ter] 2012 Jan-Mar (1), pp. 67-72. - Publication Year :
- 2012
-
Abstract
- The literature data testify the there is an early and delayed hypothermic preconditioning of brain. Neuroprotective effect of early hypothermic preconditioning is a result of activation of adenosine A1 receptors, KATP-channels. Ras protein and predetermined by a decrease in the synthesis of NO*. The infarct-sparing effect of delayed hypothermic preconditioning of brain is depended upon protein synthesis de novo. The presented data demonstrate that hypothermic preconditioning prevents cardiomyocyte necrosis in response to ischemia-reperfusion, improves pump function of the heart during reperfusion period, exerts an antiarrhythmic effect. The hypothermic preconditioning exerts more pronounced cardioprotective effect than ischemic preconditioning. The protective impact of hypothermic preconditioning is depended upon activation of protein kinase C, AMP-activated protein kinase (AMPK) and inhibition of MPT pore. The reactive oxygen species are triggers and mediators of hypothermic preconditioning of heart.
- Subjects :
- Animals
Brain pathology
Humans
Hypothermia pathology
Myocardial Reperfusion Injury metabolism
Myocardial Reperfusion Injury pathology
Myocardial Reperfusion Injury physiopathology
Myocardial Reperfusion Injury prevention & control
Myocardium pathology
Myocytes, Cardiac metabolism
Myocytes, Cardiac pathology
Necrosis
Nitric Oxide metabolism
Brain metabolism
Brain physiopathology
Heart physiopathology
Hypothermia metabolism
Hypothermia physiopathology
Ischemic Preconditioning, Myocardial
Myocardium metabolism
Subjects
Details
- Language :
- Russian
- ISSN :
- 0031-2991
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Patologicheskaia fiziologiia i eksperimental'naia terapiia
- Publication Type :
- Academic Journal
- Accession number :
- 22629865