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Susceptibility of different mice strains to okadaic acid, a diarrhetic shellfish poisoning toxin.
- Source :
-
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment [Food Addit Contam Part A Chem Anal Control Expo Risk Assess] 2012 Aug; Vol. 29 (8), pp. 1307-10. Date of Electronic Publication: 2012 May 25. - Publication Year :
- 2012
-
Abstract
- The mouse bioassay is widely used to detect diarrhetic shellfish poisoning (DSP) toxins. To the best of our knowledge, however, there have been no reports specifically on strain differences in susceptibility to DSP toxins. In this study, we investigated the susceptibility of different mice strains to okadaic acid (OA), one of the representative DSP toxins. A lethal dose of OA was injected intraperitoneally (i.p.) into mice. The mice were observed until 24 h after injection. Five inbred strains (A/J, BALB/c, C3H/He, C57BL/6, and DBA/2) and two non-inbred strains (ddY, and ICR) of mice were compared. All the mice were male, weighed 16-20 g, and were 4-5 weeks old. The lethality was 90-100% in the A/J, BALB/c, ddY, and ICR strains, 70-80% in the C3H/He and C57BL/6 strains, and 40% in DBA/2 strain. Survival analysis showed that the BALB/c, C57BL/6, ddY, and ICR strains died earlier and the A/J, C3H/He and DBA/2 strains survived longer. These results indicate that significant differences may exist in the susceptibility of mice strains to OA.
- Subjects :
- Animals
Animals, Outbred Strains
Food Inspection methods
Injections, Intraperitoneal
Japan
Male
Marine Toxins administration & dosage
Mice
Mice, Inbred Strains
Okadaic Acid administration & dosage
Species Specificity
Specific Pathogen-Free Organisms
Survival Analysis
Biological Assay methods
Disease Susceptibility
Marine Toxins toxicity
Okadaic Acid toxicity
Shellfish Poisoning etiology
Shellfish Poisoning physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1944-0057
- Volume :
- 29
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment
- Publication Type :
- Academic Journal
- Accession number :
- 22632464
- Full Text :
- https://doi.org/10.1080/19440049.2012.685892