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Primary pancreatic leiomyosarcoma: a retrospective analysis of clinical characteristics and prognosis of this rare disease.
- Source :
-
Hepato-gastroenterology [Hepatogastroenterology] 2012 Nov-Dec; Vol. 59 (120), pp. 2644-9. - Publication Year :
- 2012
-
Abstract
- Background/aims: Primary pancreatic leiomyoarcoma (PLMS) is a rare disease; its clinical characters and prognosis are poorly demonstrated. This study aimed to investigate the tumor's clinical characters and to reveal the true outcome.<br />Methodology: A retrospective review of both Chinese and worldwide PLMS patients were performed. Data was collected and analyzed and overall survival was described by Kaplan-Meier curve.<br />Results: In total, there were 9 cases identified in China and 55 cases identified in the worldwide literature. Incidence rate was general equal in gender and had an increased trend with age(mean +SD: 55+14 years). Abdominal pain, mass and weight loss were the most common presentations, mean tumor size was 10cm (SD 7.2cm) and most of them presented as a solid mass. Forty six cases accepted operation, 33 of which obtained a radical resection. Median overall survival time was 27 months.The patients who accepted radical resection had an obviously improved prognosis over non-resectable patients.<br />Conclusions: PLMS commonly occurred in the mid-age people and there was lack of specific non-invasive methods for precise preoperative diagnosis.PLMS has a much better prognosis compared with pancreatic ductal adenocarcinoma. Radical resection is the only hope for improving the outcome of this malignancy.
- Subjects :
- Abdominal Pain etiology
Adult
Age Factors
Aged
China
Female
Humans
Incidence
Kaplan-Meier Estimate
Male
Middle Aged
Pancreatectomy
Retrospective Studies
Time Factors
Treatment Outcome
Tumor Burden
Weight Loss
Leiomyosarcoma complications
Leiomyosarcoma mortality
Leiomyosarcoma pathology
Leiomyosarcoma surgery
Pancreatic Neoplasms complications
Pancreatic Neoplasms mortality
Pancreatic Neoplasms pathology
Pancreatic Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 0172-6390
- Volume :
- 59
- Issue :
- 120
- Database :
- MEDLINE
- Journal :
- Hepato-gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 22641076
- Full Text :
- https://doi.org/10.5754/hge12273