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ω-3 polyunsaturated fatty acid supplementation does not influence body composition, insulin resistance, and lipemia in women with type 2 diabetes and obesity.
- Source :
-
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition [Nutr Clin Pract] 2012 Aug; Vol. 27 (4), pp. 553-60. Date of Electronic Publication: 2012 Jun 01. - Publication Year :
- 2012
-
Abstract
- To evaluate the influence of ω-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on body composition, insulin resistance, and lipemia of women with type 2 diabetes, the authors evaluated 41 women (60.64 ± 7.82 years) with high blood pressure and diabetes mellitus in a randomized and single-blind longitudinal intervention study. The women were divided into 3 groups: GA (2.5 g/d fish oil), GB (1.5 g/d fish oil), and GC (control). The capsules with the supplement contained 21.9% of eicosapentaenoic acid and 14.1% of docosapentaenoic acid. Biochemical (glucose, glycated hemoglobin, total and fractional cholesterol, triglycerides, and insulin) and anthropometric (body mass, stature, waist circumference [WC], and body composition) evaluations were performed before and after the 30 days of intervention. Homeostasis model assessment-insulin resistance and the Quantitative Insulin Sensitivity Check Index were used to evaluate the insulin resistance and insulin sensitivity (IS), respectively. GB presented a greater loss of body mass and WC (P < .05), greater frequency of glycemic and total cholesterol reduction, and an increase of high-density lipoprotein cholesterol compared with GA. Thus, a high dose of ω-3 PUFA can reduce IS. A lower dose of ω-3 PUFA positively influenced body composition and lipid metabolism.
- Subjects :
- Aged
Blood Glucose analysis
Body Mass Index
Cholesterol blood
Diabetes Mellitus, Type 2 drug therapy
Diabetes Mellitus, Type 2 physiopathology
Female
Fish Oils administration & dosage
Glycated Hemoglobin analysis
Humans
Hyperlipidemias physiopathology
Insulin blood
Middle Aged
Obesity drug therapy
Obesity physiopathology
Single-Blind Method
Triglycerides blood
Waist Circumference
Body Composition
Dietary Supplements
Eicosapentaenoic Acid administration & dosage
Fatty Acids, Unsaturated administration & dosage
Hyperlipidemias drug therapy
Insulin Resistance
Subjects
Details
- Language :
- English
- ISSN :
- 1941-2452
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 22661243
- Full Text :
- https://doi.org/10.1177/0884533612444535