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Effect of L-deprenyl treatment on electrical activity, Na+, K+ ATPase, and protein kinase C activities in hippocampal subfields (CA1 and CA3) of aged rat brain.
- Source :
-
Indian journal of experimental biology [Indian J Exp Biol] 2012 Feb; Vol. 50 (2), pp. 101-9. - Publication Year :
- 2012
-
Abstract
- L-deprenyl is considered to protect against age-related cognitive deficits by improving long-term learning/memory in the aged brain. The CA1 and CA3 hippocampal areas are the sites at which initial learning and memory processes occur. Chronic deprenyl treatment significantly augmented the basal electrical firing rate (multiple-unit action potentials), and Na+, K(+)-ATPase and protein kinase C activities of both CA1 and CA3 indicating that the drug increased the excitability of CA1 and CA3. The increase, however, was much greater in CA1 than in CA3 suggesting that deprenyl can improve longer-term learning in aged animals by its excitability-enhancing action in CA1. The drug also countered the ageing-related loss of hippocampal protein kinase C activity.
- Subjects :
- Action Potentials drug effects
Aging drug effects
Animals
CA1 Region, Hippocampal enzymology
CA1 Region, Hippocampal physiology
CA3 Region, Hippocampal enzymology
CA3 Region, Hippocampal physiology
Electroencephalography
Learning drug effects
Male
Rats
Rats, Wistar
Reaction Time drug effects
Regression Analysis
Aging physiology
CA1 Region, Hippocampal drug effects
CA3 Region, Hippocampal drug effects
Electrophysiological Phenomena drug effects
Protein Kinase C metabolism
Selegiline pharmacology
Sodium-Potassium-Exchanging ATPase metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0019-5189
- Volume :
- 50
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Indian journal of experimental biology
- Publication Type :
- Academic Journal
- Accession number :
- 22670472