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Attenuation of collagen-induced arthritis by orally available imidazoline-based NF-κB inhibitors.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Jul 15; Vol. 22 (14), pp. 4816-9. Date of Electronic Publication: 2012 May 18. - Publication Year :
- 2012
-
Abstract
- The pathogenesis of rheumatoid arthritis is mainly driven by NF-κB-mediated production of cytokines, such as TNF-α. We report herein that the orally available imidazoline-based NF-κB inhibitor, TCH-013, was found to significantly reduce TNF-α signaling and attenuate collagen antibody induced arthritis in BALB/c mice.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Administration, Oral
Animals
Arthritis, Experimental immunology
Imidazolines administration & dosage
Imidazolines chemical synthesis
Mice
Mice, Inbred BALB C
Tumor Necrosis Factor-alpha biosynthesis
Tumor Necrosis Factor-alpha immunology
Arthritis, Experimental drug therapy
Imidazolines therapeutic use
NF-kappa B antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 22
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 22682057
- Full Text :
- https://doi.org/10.1016/j.bmcl.2012.05.056