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GDNF released from microspheres enhances nerve regeneration after delayed repair.
- Source :
-
Muscle & nerve [Muscle Nerve] 2012 Jul; Vol. 46 (1), pp. 122-4. - Publication Year :
- 2012
-
Abstract
- Introduction: Delays in surgical repair following nerve transection produce progressively inferior motor nerve regeneration. Regeneration can be improved with delivery of exogenous growth factor. We developed a delivery system that could be applied at the nerve repair site to deliver growth factors locally to regenerating nerve.<br />Methods: Poly(lactic-co-glycolic acid) microspheres containing glial-derived neurotrophic factor (GDNF) suspended within fibrin were developed into a delivery system for local application surrounding nerve at a repair site in an experimental rat model.<br />Results: The system containing GDNF remained at the injury site for up to 2 weeks and improved motor nerve regeneration following chronic axotomy and denervation.<br />Conclusions: Based on the positive outcome of the delivery system, we plan to study the delivery system over longer time courses of release and nerve regeneration.<br /> (Copyright © 2012 Wiley Periodicals, Inc.)
Details
- Language :
- English
- ISSN :
- 1097-4598
- Volume :
- 46
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Muscle & nerve
- Publication Type :
- Academic Journal
- Accession number :
- 22692999
- Full Text :
- https://doi.org/10.1002/mus.23295