The increased expression of CD11c and CD103 molecules in the neutrophils of the peripheral blood treated with a formula of bacterial ribosomes and proteoglycans of Klebsiella pneumoniae.

Aim: To evaluate the effect of a preparation with bacterial ribosomes and proteoglycans from Klebsiella pneumoniae «R» on the in vitro expression of CD11c and CD103 molecules in neutrophils from peripheral blood.
Methods: Isolation of neutrophils from peripheral blood with Ficoll-Paque, incubation with R and detection of CD11c and CD103 through flow cytometry.
Results: Six hours after the incubation period, CD11c expression increased significantly compared with the control with 125 and 500μg/ml of R (P=.017 and P=.006, respectively). CD103 expression induced with 125μg/ml of R after 6hours was significantly higher than that observed after 4hours at the same concentration (P=.014) and that found with 62.5μg/ml (P=.017) of R.
Conclusions: The increased expression of CD11c and CD103 induced by R in the neutrophils could contribute to the R mechanism against respiratory pathogens.
(Copyright © 2012 SEPAR. Published by Elsevier Espana. All rights reserved.)