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Sunitinib malate in solitary fibrous tumor (SFT).
- Source :
-
Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2012 Dec; Vol. 23 (12), pp. 3171-3179. Date of Electronic Publication: 2012 Jun 17. - Publication Year :
- 2012
-
Abstract
- Background: To report on sunitinib activity in a retrospective series of 35 solitary fibrous tumor (SFT) treated at a single institution.<br />Patients and Methods: From April 2008, 35 patients with progressive advanced SFT (male/female: 20/15; mean age: 58 years; meningeal/extrameningeal: 6/29; locally advanced/metastatic: 15/20; prior chemotherapy: 25) were treated, on an individual use basis, with continuous-dosing sunitinib 37.5 mg/day. Platelet-derived growth factor receptor beta (PDGFRB) and vascular endothelial growth factor receptor 2 (VEGFR2) status were assessed by immunohistochemistry and, in a subgroup of patients, by real time PCR.<br />Results: Thirty-one patients were assessable for response by RECIST (one early death; three early interruptions). Best responses were 2 partial response (PR), 16 stable disease, 13 progressive disease. A <30% decrease in size was observed in three patients. Fourteen of 29 patients assessable by Choi criteria had a PR. Median progression-free survival by RECIST was 6 months (range 1-22). In two of six patients, resistance to sunitinib was overcome by increasing sunitinib to 50 mg/day. PDGFRB and/or VEGFR2 were positive in all cases and not predictive of response; a less aggressive morphology corresponded to an increased response rate (53% PR by Choi in the malignant SFT, 20% PR in the pleomorphic/dedifferentiated SFT).<br />Conclusions: Sunitinib is active in SFT. Response can be long-lasting.
- Subjects :
- Adult
Aged
Angiogenesis Inhibitors therapeutic use
Antigens, CD34 metabolism
Antineoplastic Agents therapeutic use
Disease Progression
Disease-Free Survival
Female
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Proto-Oncogene Proteins c-bcl-2 metabolism
Receptor, Platelet-Derived Growth Factor beta metabolism
Retrospective Studies
Sunitinib
Treatment Outcome
Vascular Endothelial Growth Factor Receptor-2 metabolism
Indoles therapeutic use
Pyrroles therapeutic use
Solitary Fibrous Tumors drug therapy
Solitary Fibrous Tumors mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1569-8041
- Volume :
- 23
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Annals of oncology : official journal of the European Society for Medical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 22711763
- Full Text :
- https://doi.org/10.1093/annonc/mds143