Fluoroform-derived CuCF3 for low-cost, simple, efficient, and safe trifluoromethylation of aryl boronic acids in air.

Authors :: Novák P
Lishchynskyi A
Grushin VV
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2012 Jul 27; Vol. 51 (31), pp. 7767-70. Date of Electronic Publication: 2012 Jun 19.
Publication Year :: 2012
Abstract: Easy does it: Aryl boronic acids undergo smooth and selective trifluoromethylation with low-cost fluoroform-derived CuCF(3) in DMF in non-dried air. The reaction occurs under mild conditions (1 atm, room temperature), exhibits unprecedented functional-group tolerance, and affords trifluoromethylated aromatic compounds in up to 99 % yield.<br /> (Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Air
Hydrocarbons, Fluorinated chemistry
Molecular Structure
Stereoisomerism
Boronic Acids chemistry
Hydrocarbons, Fluorinated chemical synthesis
Organometallic Compounds chemistry

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