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[Observation on effect of badu shengji san and its decomposed recipes on morphological changes of injured skin tissues in rats].
- Source :
-
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2012 Mar; Vol. 37 (6), pp. 715-8. - Publication Year :
- 2012
-
Abstract
- Objective: To study the effect of Badu Shengji San (BDSJS) and its decomposed recipes on morphological changes of injured skin in rats.<br />Method: SD rats with injured skin were treated with BDSJS and its different decomposed recipes for consecutively 14 days. Morphological changes in the injured skin were observed by H&E staining.<br />Result: Mercury and lead-containing ingredients significantly decreased epidermal thickness and caused vascular hemorrhage, hyperemia and inflammatory cell infiltration in reticular layer of dermis. The compatible herbs alleviated epidermal thickness and reduced dermal lesions.<br />Conclusion: BDSJS' mercury and lead-containing ingredients can accelerate the healing of skin wound and its compatible herbs can relieve the dermis injury induced by mercury and lead.
- Subjects :
- Animals
Drugs, Chinese Herbal chemistry
Drugs, Chinese Herbal toxicity
Epidermis drug effects
Epidermis injuries
Epidermis pathology
Hemorrhage chemically induced
Hyperemia chemically induced
Male
Random Allocation
Rats
Rats, Sprague-Dawley
Skin injuries
Skin pathology
Skin Diseases drug therapy
Skin Diseases pathology
Drugs, Chinese Herbal pharmacology
Lead toxicity
Mercury toxicity
Skin drug effects
Wound Healing drug effects
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-5302
- Volume :
- 37
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Publication Type :
- Academic Journal
- Accession number :
- 22715706