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Evaluation of thermal and non-thermal effects of UHF RFID exposure on biological drugs.
- Source :
-
IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society [IEEE Trans Inf Technol Biomed] 2012 Nov; Vol. 16 (6), pp. 1051-57. Date of Electronic Publication: 2012 Jun 14. - Publication Year :
- 2012
-
Abstract
- The Radio Frequency Identification (RFID) technology promises to improve several processes in the healthcare scenario, especially those related to traceability of people and things. Unfortunately, there are still some barriers limiting the large-scale deployment of these innovative technologies in the healthcare field. Among these, the evaluation of potential thermal and non-thermal effects due to the exposure of biopharmaceutical products to electromagnetic fields is very challenging, but still slightly investigated. This paper aims to setup a controlled RF exposure environment, in order to reproduce a worst-case exposure of pharmaceutical products to the electromagnetic fields generated by the UHF RFID devices placed along the supply chain. Radiated powers several times higher than recommended by current normative limits were applied (10 W and 20 W). The electric field strength at the exposed sample location, used in tests, was as high as 100 V/m. Non-thermal effects were evaluated by chromatography techniques and in vitro assays. The results obtained for a particular case study, the ActrapidTM human insulin preparation, showed temperature increases lower than 0.5 °C and no significant changes in the structure and performance of the considered drug.
- Subjects :
- Drug Packaging
Hot Temperature
Humans
Insulin, Regular, Pork
Materials Management, Hospital
Models, Chemical
Pharmaceutical Preparations supply & distribution
Radio Waves
Electromagnetic Fields
Pharmaceutical Preparations chemistry
Pharmaceutical Preparations radiation effects
Radio Frequency Identification Device
Subjects
Details
- Language :
- English
- ISSN :
- 1558-0032
- Volume :
- 16
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society
- Publication Type :
- Academic Journal
- Accession number :
- 22717524
- Full Text :
- https://doi.org/10.1109/TITB.2012.2204895