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Pharmacological treatment of intermittent claudication does not have a significant effect on gait impairments during claudication pain.
- Source :
-
Journal of applied biomechanics [J Appl Biomech] 2012 May; Vol. 28 (2), pp. 184-91. - Publication Year :
- 2012
-
Abstract
- Peripheral arterial disease (PAD) is a manifestation of atherosclerosis resulting in intermittent claudication (IC) or leg pain during physical activity. Two drugs (cilostazol and pentoxifylline) are approved for treatment of IC. Our previous work has reported no significant differences in gait biomechanics before and after drug interventions when PAD patients walked without pain. However, it is possible that the drugs are more efficacious during gait with pain. Our aim was to use advanced biomechanical analysis to evaluate the effectiveness of these drugs while walking with pain. Initial and absolute claudication distances, joint kinematics, torques, powers, and gait velocity during the presence of pain were measured from 24 patients before and after 12 weeks of treatment with either cilostazol or pentoxifylline. We found no significant improvements after 12 weeks of treatment with either cilostazol or pentoxifylline on the gait biomechanics of PAD patients during pain. Our findings indicate that the medications cilostazol and pentoxifylline have reduced relevance in the care of gait dysfunction even during pain in patients with PAD.
- Subjects :
- Aged
Analgesics therapeutic use
Cilostazol
Gait Disorders, Neurologic etiology
Humans
Intermittent Claudication complications
Male
Neuroprotective Agents therapeutic use
Phosphodiesterase Inhibitors therapeutic use
Treatment Outcome
Gait drug effects
Gait Disorders, Neurologic physiopathology
Gait Disorders, Neurologic prevention & control
Intermittent Claudication drug therapy
Intermittent Claudication physiopathology
Pentoxifylline therapeutic use
Tetrazoles therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1543-2688
- Volume :
- 28
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of applied biomechanics
- Publication Type :
- Academic Journal
- Accession number :
- 22723116
- Full Text :
- https://doi.org/10.1123/jab.28.2.184