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[The importance of medical genetics study for the early diagnosis of mucoviscidosis].

Authors :
Livshits LA
Gorovenko NG
Ivashchenko TE
Buzhievskaia TI
Source :
Vrachebnoe delo [Vrach Delo] 1990 Apr (4), pp. 101-3.
Publication Year :
1990

Abstract

The method of specific DNA amplification was used to study the polymorphism of the length of restriction fragment in the system CS-7 and KM-19 locus D7S23 in the family C. It is shown that cohesion of alleles A2 and B2 with mutation of mucoviscidosis and presence of a mucoviscidosis gene occurred in a healthy sibling. The family C, is prospective for prenatal diagnosis of mucoviscidosis by the method of specific DNA amplification in the system KM-19 restrictase Pst-1 and CS-7-Hinf-6-1.

Details

Language :
Russian
ISSN :
0049-6804
Issue :
4
Database :
MEDLINE
Journal :
Vrachebnoe delo
Publication Type :
Academic Journal
Accession number :
2275139