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The development of immune-modulating compounds to disrupt HIV latency.
- Source :
-
Cytokine & growth factor reviews [Cytokine Growth Factor Rev] 2012 Aug-Oct; Vol. 23 (4-5), pp. 159-72. Date of Electronic Publication: 2012 Jul 04. - Publication Year :
- 2012
-
Abstract
- Antiretroviral therapy (ART) has proved highly effective in suppressing HIV-1 replication and disease progression. Nevertheless, ART has failed to eliminate the virus from infected individuals. The main obstacle to HIV-1 eradication is the persistence of cellular viral reservoirs. Therefore, the "shock-and-kill" strategy was proposed consisting of inducing HIV-1 escape from latency, in the presence of ART. This is followed by the elimination of reactivated, virus-producing cells. Immune modulators, including protein kinase C (PKC) activators, anti-leukemic drugs and histone deacetylase inhibitors (HDACis) have all demonstrated efficacy in the reactivation of latent virus replication. This review will focus on the potential use of these small molecules in the "shock and kill" strategy, the molecular basis for their action and the potential advantages of their immune-modulating activities.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Anti-HIV Agents immunology
CD4-Positive T-Lymphocytes drug effects
CD4-Positive T-Lymphocytes immunology
CD4-Positive T-Lymphocytes virology
HIV Infections immunology
HIV Infections virology
HIV-1 immunology
HIV-1 physiology
Host-Pathogen Interactions drug effects
Host-Pathogen Interactions immunology
Humans
Immunologic Factors immunology
Models, Immunological
Virus Activation drug effects
Virus Activation immunology
Virus Latency immunology
Anti-HIV Agents therapeutic use
HIV Infections prevention & control
HIV-1 drug effects
Immunologic Factors therapeutic use
Virus Latency drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0305
- Volume :
- 23
- Issue :
- 4-5
- Database :
- MEDLINE
- Journal :
- Cytokine & growth factor reviews
- Publication Type :
- Academic Journal
- Accession number :
- 22766356
- Full Text :
- https://doi.org/10.1016/j.cytogfr.2012.05.003