Toxicity studies of butylated hydroxyanisole and butylated hydroxytoluene. II. Chronic feeding studies.

Authors :: Williams GM
Wang CX
Iatropoulos MJ
Source :: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 1990 Dec; Vol. 28 (12), pp. 799-806.
Publication Year :: 1990
Abstract: The antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) were fed in the diet to male F344 rats in two chronic feeding studies. In one study, feeding BHT for 76 wk at concentrations ranging from 100 to 6000 ppm produced no increase in neoplasms at any site. In a second study, feeding 12,000 ppm BHT for 110 wk had no neoplastic effect at any site, whereas feeding BHA at 12,000 ppm resulted in a small increase in squamous cell papillomas of the non-glandular squamous portion of the stomach.

Subjects :: Animals
Body Weight drug effects
Butylated Hydroxyanisole administration & dosage
Butylated Hydroxytoluene administration & dosage
Diet
Hyperplasia
Liver drug effects
Male
Organ Size drug effects
Papilloma chemically induced
Rats
Rats, Inbred F344
Butylated Hydroxyanisole toxicity
Butylated Hydroxytoluene toxicity
Liver Neoplasms chemically induced
Neoplasms chemically induced
Stomach Neoplasms chemically induced

Language :: English
ISSN :: 0278-6915
Volume :: 28
Issue :: 12
Database :: MEDLINE
Journal :: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Publication Type :: Academic Journal
Accession number :: 2276703
Full Text :: https://doi.org/10.1016/0278-6915(90)90052-o

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