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The effects of phentolamine on fructose-fed rats.
- Source :
-
Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2012 Aug; Vol. 90 (8), pp. 1075-85. Date of Electronic Publication: 2012 Jul 11. - Publication Year :
- 2012
-
Abstract
- Metabolic syndrome (MS) is a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes. MS is associated with obesity, increased blood pressure, hyperlipidemia, and hyperglycemia. This study was designed to investigate the pharmacological profile of phentolamine, a nonselective α adrenergic receptor antagonist, in the prevention of increased blood pressure in fructose-fed rats. Phentolamine prevented the fructose-induced increase in systolic blood pressure without affecting insulin sensitivity and major metabolic parameters. The levels of plasma noradrenaline and angiotensin II, 2 proposed contributors to the development of fructose-induced elevated blood pressure, were examined. Neither noradrenaline nor angiotensin II levels were affected by phentolamine treatment. Since overproduction of nitric oxide has been shown to lead to an elevation in peroxynitrite, the role of oxidative stress, a proposed mechanism of fructose-induced elevated blood pressure and insulin resistance, was examined by measuring plasma levels of total nitrate/nitrite. Plasma nitrate/nitrite was significantly elevated in all fructose-fed animals, regardless of treatment with phentolamine. Another proposed contributor toward fructose-induced MS is an elevation in uric acid levels. In this experiment, plasma levels of uric acid were found to be increased by dietary fructose and were unaffected by phentolamine treatment.
- Subjects :
- Adrenergic alpha-Antagonists pharmacology
Angiotensin II blood
Animals
Blood Glucose drug effects
Blood Pressure drug effects
Blood Pressure physiology
Disease Models, Animal
Fructose
Hypertension blood
Hypertension physiopathology
Insulin blood
Male
Metabolic Syndrome blood
Metabolic Syndrome chemically induced
Metabolic Syndrome physiopathology
Norepinephrine blood
Phentolamine pharmacology
Rats
Rats, Wistar
Reactive Nitrogen Species blood
Uric Acid blood
Adrenergic alpha-Antagonists therapeutic use
Hypertension drug therapy
Metabolic Syndrome drug therapy
Phentolamine therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1205-7541
- Volume :
- 90
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Canadian journal of physiology and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 22783820
- Full Text :
- https://doi.org/10.1139/y2012-063