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Phytoceramides and acylated phytosterol glucosides from Pterospermum acerifolium Willd. seed coat and their osteogenic activity.
- Source :
-
Phytochemistry [Phytochemistry] 2012 Sep; Vol. 81, pp. 117-25. Date of Electronic Publication: 2012 Jul 10. - Publication Year :
- 2012
-
Abstract
- Phytochemical investigation of seed coats of Pterospermum acerifolium afforded two phytoceramides (1, 2) and two acylated phytosterol glucosides (3, 4) together with five known compounds (5-9). Their structures were elucidated on the basis of extensive spectroscopic analysis using 1D, 2D NMR and Mass spectrometry. Compounds 1, 2, 3, and 4 were assessed for their osteogenic activity using primary cultures of osteoblasts harvested from neonatal rat calvaria. Among these compounds, 1 and 2 markedly stimulated osteoblast differentiation assessed by alkaline phosphatase production and osteoblast mineralization by alizarin red-S staining.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Acylation
Alkaline Phosphatase analysis
Alkaline Phosphatase chemistry
Animals
Anthraquinones chemistry
Bone Marrow Cells drug effects
Bone Morphogenetic Protein 2 chemistry
Calcification, Physiologic
Cell Differentiation
Ceramides pharmacology
Core Binding Factor Alpha 1 Subunit chemistry
Hydrolysis
Magnetic Resonance Spectroscopy
Molecular Structure
Osteogenesis
Phytosterols pharmacology
Primary Cell Culture
Rats
Skull chemistry
Skull drug effects
Ceramides chemistry
Glucosides chemistry
Malvaceae chemistry
Osteoblasts drug effects
Phytosterols chemistry
Seeds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3700
- Volume :
- 81
- Database :
- MEDLINE
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 22784550
- Full Text :
- https://doi.org/10.1016/j.phytochem.2012.06.005