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Nicotine and pathological angiogenesis.
- Source :
-
Life sciences [Life Sci] 2012 Nov 27; Vol. 91 (21-22), pp. 1058-64. Date of Electronic Publication: 2012 Jul 13. - Publication Year :
- 2012
-
Abstract
- This paper describes the role of endothelial nicotinic acetylcholine receptors (nAChR) in diseases where pathological angiogenesis plays a role. An extensive review of the literature was performed, focusing on studies that investigated the effect of nicotine upon angiogenesis. Nicotine induces pathological angiogenesis at clinically relevant concentrations (i.e. at tissue and plasma concentrations similar to those of a light to moderate smoker). Nicotine promotes endothelial cell migration, proliferation, survival, tube formation and nitric oxide (NO) production in vitro, mimicking the effect of other angiogenic growth factors. These in vitro findings indicate that there may be an angiogenic component to the pathophysiology of major tobacco related diseases such as carcinoma, atherosclerosis, and age-related macular degeneration. Indeed, nicotine stimulates pathological angiogenesis in pre-clinical models of these disorders. Subsequently, it has been demonstrated that nicotine stimulates nAChRs on the endothelium to induce angiogenic processes, that these nAChRs are largely of the α7 homomeric type, and that there are synergistic interactions between the nAChRs and angiogenic growth factor receptors at the phosphoproteomic and genomic levels. These findings are of potential clinical relevance, and provide mechanistic insights into tobacco-related disease. Furthermore, these findings may lead to novel therapies for diseases characterized by insufficient or inappropriate angiogenesis.<br /> (Copyright © 2012. Published by Elsevier Inc.)
- Subjects :
- Animals
Atherosclerosis metabolism
Atherosclerosis pathology
Endothelium drug effects
Endothelium pathology
Humans
Neoplasms metabolism
Neoplasms pathology
Neovascularization, Pathologic metabolism
Neovascularization, Pathologic pathology
Nicotine metabolism
Smoking adverse effects
Smoking metabolism
Atherosclerosis chemically induced
Endothelium metabolism
Neoplasms chemically induced
Neovascularization, Pathologic chemically induced
Nicotine adverse effects
Receptors, Nicotinic metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0631
- Volume :
- 91
- Issue :
- 21-22
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 22796717
- Full Text :
- https://doi.org/10.1016/j.lfs.2012.06.032