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Recent advances in neuraminidase inhibitor development as anti-influenza drugs.
- Source :
-
ChemMedChem [ChemMedChem] 2012 Sep; Vol. 7 (9), pp. 1527-36. Date of Electronic Publication: 2012 Jul 16. - Publication Year :
- 2012
-
Abstract
- The recent emergence of the highly pathogenic H5N1 subtype of avian influenza virus (AIV) and of the new type of human influenza A (H1N1) have emphasized the need for the development of effective anti-influenza drugs. Presently, neuraminidase (NA) inhibitors are widely used in the treatment and prophylaxis of human influenza virus infection, and tremendous efforts have been made to develop more potent NA inhibitors to combat resistance and new influenza viruses. In this review, we discuss the structural characteristics of NA catalytic domains and the recent developments of new NA inhibitors using structure-based drug design strategies. These drugs include analogues of zanamivir, analogues of oseltamivir, analogues of peramivir, and analogues of aromatic carboxylic acid and present promising options for therapeutics or leads for further development of NA inhibitors that may be useful in the event of a future influenza pandemic.<br /> (Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Acids, Carbocyclic
Animals
Benzoic Acid chemistry
Benzoic Acid pharmacology
Cyclopentanes chemistry
Cyclopentanes pharmacology
Enzyme Inhibitors chemistry
Enzyme Inhibitors pharmacology
Guanidines chemistry
Guanidines pharmacology
Humans
Influenza A Virus, H1N1 Subtype drug effects
Influenza A Virus, H1N1 Subtype enzymology
Influenza A Virus, H5N1 Subtype drug effects
Influenza A Virus, H5N1 Subtype enzymology
Influenza, Human drug therapy
Models, Molecular
Neuraminidase chemistry
Neuraminidase metabolism
Orthomyxoviridae drug effects
Orthomyxoviridae Infections drug therapy
Oseltamivir chemistry
Oseltamivir pharmacology
Zanamivir chemistry
Zanamivir pharmacology
Antiviral Agents chemistry
Antiviral Agents pharmacology
Drug Design
Neuraminidase antagonists & inhibitors
Orthomyxoviridae enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1860-7187
- Volume :
- 7
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- ChemMedChem
- Publication Type :
- Academic Journal
- Accession number :
- 22807317
- Full Text :
- https://doi.org/10.1002/cmdc.201200155