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Xerostomia: a day and night difference.
- Source :
-
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2012 Aug; Vol. 104 (2), pp. 219-23. Date of Electronic Publication: 2012 Jul 17. - Publication Year :
- 2012
-
Abstract
- Purpose: To compare patient-reported xerostomia during daytime and during nighttime with objectively measured parotid and submandibular gland function in a cohort of head-and-neck cancer (HNC) patients treated with RT.<br />Materials and Methods: A cohort of 138 HNC patients underwent objective measurements of parotid (PF) and submandibular (SMF) gland function and completed a xerostomia questionnaire (XQ) before RT, at 6 weeks, 6 months and 1 year after RT. No attempt was made to spare the submandibular gland(s). The XQ contained specific questions concerning the sensation of dry mouth during day- (XD) and nighttime (XN), scored on a 5-point Likert scale. Patients with no or mild (grade 1-3) xerostomia and patients with more severe (grade 4-5) complaints were grouped together.<br />Results: Before RT, no association existed between dry mouth complaints and PF or SMF. At 6 weeks, 6 months and 1 year after RT; 37%, 51% and 36% had grade 4-5 XD and 65%, 64% and 56% had grade 4-5 XN, respectively. Patients with grade 4-5 XD and XN had significantly worse SMF at all time points after RT compared to patients with grade 1-3 XD and XN, while PF was significantly worse only at 6 weeks after RT. In multivariate analyses, SMF was consistently the most important factor related to XN after treatment. PF significantly influenced XD at 6 weeks and 1 year after RT.<br />Conclusions: Differentiating between complaints during day- and nighttime in xerostomia research is necessary. Dry mouth at night is a frequent problem after (parotid-sparing) RT for HNC and is explained by submandibular gland dysfunction. Sparing of the contralateral submandibular gland, in addition to parotid gland sparing, may result in improved patient-reported xerostomia.<br /> (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Dose-Response Relationship, Radiation
Double-Blind Method
Female
Head and Neck Neoplasms drug therapy
Head and Neck Neoplasms pathology
Humans
Male
Middle Aged
Multivariate Analysis
Parotid Gland radiation effects
Pilocarpine therapeutic use
Quality of Life
Radiation Dosage
Radiotherapy, Intensity-Modulated methods
Risk Assessment
Statistics, Nonparametric
Xerostomia drug therapy
Circadian Rhythm
Head and Neck Neoplasms radiotherapy
Radiotherapy, Intensity-Modulated adverse effects
Salivation radiation effects
Xerostomia etiology
Xerostomia physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0887
- Volume :
- 104
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 22809589
- Full Text :
- https://doi.org/10.1016/j.radonc.2012.06.004