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Synthesis of taxane ABC tricyclic skeleton from lycoctonine.

Authors :
Liang XX
Tang P
Chen QH
Wang FP
Source :
Natural product communications [Nat Prod Commun] 2012 Jun; Vol. 7 (6), pp. 697-703.
Publication Year :
2012

Abstract

A new conversional synthesis of the ABC ring system of taxoids from the C19-diterpenoid alkaloid lycoctonine was developed in 6 steps with 2% overall yield. The distinctive features of the conversion include pinacol rearrangement, enlargement of ring B, and opening of a four-membered ring.

Subjects

Subjects :
Aconitine chemistry
Molecular Structure
Aconitine analogs & derivatives
Alkaloids chemical synthesis
Alkaloids chemistry
Bridged-Ring Compounds chemistry
Diterpenes chemical synthesis
Diterpenes chemistry
Taxoids chemistry

Details

Language :
English
ISSN :
1934-578X
Volume :
7
Issue :
6
Database :
MEDLINE
Journal :
Natural product communications
Publication Type :
Academic Journal
Accession number :
22816287

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