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Electrospun nanofibers in drug delivery: recent developments and perspectives.
- Source :
-
Therapeutic delivery [Ther Deliv] 2012 Apr; Vol. 3 (4), pp. 515-33. - Publication Year :
- 2012
-
Abstract
- In this review article, some key challenges in drug delivery are first introduced and methods that have been applied in attempts to solve them enumerated. Particularly intractable problems are highlighted: these include issues of solubility, targeting and drug degradation. The technique of electrospinning is subsequently introduced, and the influence of processing parameters on the fibers produced discussed. The potential of electrospun nanofibers in drug delivery is then explored, with examples given from the recent literature to illustrate how fibers can be used to overcome hurdles in drug solubility, degradation and targeting. Future perspectives and challenges are also considered.
- Subjects :
- Animals
Biological Transport
Chemistry, Pharmaceutical trends
Drug Compounding trends
Drug Stability
Gene Transfer Techniques trends
Humans
Pharmaceutical Preparations administration & dosage
Pharmaceutical Preparations metabolism
Solubility
Drug Carriers
Drug Delivery Systems trends
Nanofibers
Pharmaceutical Preparations chemistry
Technology, Pharmaceutical trends
Subjects
Details
- Language :
- English
- ISSN :
- 2041-5990
- Volume :
- 3
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Therapeutic delivery
- Publication Type :
- Academic Journal
- Accession number :
- 22834080
- Full Text :
- https://doi.org/10.4155/tde.12.17