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Oral administration of apigenin inhibits metastasis through AKT/P70S6K1/MMP-9 pathway in orthotopic ovarian tumor model.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2012; Vol. 13 (6), pp. 7271-7282. Date of Electronic Publication: 2012 Jun 13. - Publication Year :
- 2012
-
Abstract
- Apigenin, a flavonoid commonly present in the daily diet, is known for its potential anti-tumor properties. However, the effect of apigenin via oral administration on tumor growth and metastasis remains unknown. In this study we developed an orthotopic ovarian tumor model in nude mice to test the effect of apigenin oral administration, and showed that apigenin inhibited the micrometastasis of cancer cells in the animal tumor model. To understand the mechanism of apigenin in inhibiting metastasis, we found that apigenin greatly inhibited MMP-9 expression and p-AKT and p-p70S6K1 levels in the tumor tissues compared to the control group. We further demonstrated that the downregulation of MMP-9 by apigenin was mediated by the AKT/p70S6K1 pathway. These findings help to address the question with common interests to the public of whether oral uptake of flavonoids is effective in preventing cancer. Our results demonstrate for the first time that oral uptake of apigenin can inhibit tumor metastasis through MMP-9 expression using the orthotopic ovarian tumor model.
- Subjects :
- Administration, Oral
Animals
Cell Line, Tumor
Female
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasms, Experimental metabolism
Neoplasms, Experimental pathology
Ovarian Neoplasms metabolism
Ovarian Neoplasms pathology
Apigenin pharmacology
Matrix Metalloproteinase 9 metabolism
Neoplasms, Experimental drug therapy
Ovarian Neoplasms drug therapy
Proto-Oncogene Proteins c-akt metabolism
Ribosomal Protein S6 Kinases, 70-kDa metabolism
Signal Transduction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 13
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 22837693
- Full Text :
- https://doi.org/10.3390/ijms13067271