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Polydatin attenuates hypoxic pulmonary hypertension and reverses remodeling through protein kinase C mechanisms.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2012; Vol. 13 (6), pp. 7776-7787. Date of Electronic Publication: 2012 Jun 21. - Publication Year :
- 2012
-
Abstract
- Hypoxic pulmonary hypertension is a life-threatening emergency if untreated. Consistent pulmonary hypertension also leads to arteries and ventricular remodeling. The clinical therapeutic strategy for pulmonary hypertension and the corresponding remodeling mainly interacts with NO, angiotensin II (Ang II) and elevated endothelin (ET) targets. In the present study, we evaluated the effects of polydatin on hypoxia-induced pulmonary hypertension. It was observed that polydatin attenuated hypoxic pulmonary hypertension, reversed remodeling, and regulated NO, Ang II, ET contents in the serum and lung samples. However, forced activation of PKC signaling by its selective activator thymeleatoxin (THX) could abate the effects of polydatain. These results suggest that polydatin might be a promising candidate for hypoxic pulmonary treatment through interaction with PKC mechanisms.
- Subjects :
- Angiotensin II metabolism
Animals
Endothelins metabolism
Hypertension, Pulmonary metabolism
Hypertension, Pulmonary pathology
Hypertension, Pulmonary physiopathology
Hypoxia metabolism
Hypoxia pathology
Hypoxia physiopathology
Male
Nitric Oxide metabolism
Phorbol Esters pharmacology
Protein Kinase C antagonists & inhibitors
Rats
Rats, Sprague-Dawley
Glucosides pharmacology
Hypertension, Pulmonary drug therapy
Hypoxia drug therapy
Protein Kinase C metabolism
Signal Transduction drug effects
Stilbenes pharmacology
Vascular Remodeling drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 13
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 22837726
- Full Text :
- https://doi.org/10.3390/ijms13067776