Back to Search
Start Over
Therapeutic angiogenesis: controlled delivery of angiogenic factors.
- Source :
-
Therapeutic delivery [Ther Deliv] 2012 Jun; Vol. 3 (6), pp. 693-714. - Publication Year :
- 2012
-
Abstract
- Therapeutic angiogenesis aims at treating ischemic diseases by generating new blood vessels from existing vasculature. It relies on delivery of exogenous factors to stimulate neovasculature formation. Current strategies using genes, proteins and cells have demonstrated efficacy in animal models. However, clinical translation of any of the three approaches has proved to be challenging for various reasons. Administration of angiogenic factors is generally considered safe, according to accumulated trials, and offers off-the-shelf availability. However, many hurdles must be overcome before therapeutic angiogenesis can become a true human therapy. This article will highlight protein-based therapeutic angiogenesis, concisely review recent progress and examine critical challenges. We will discuss growth factors that have been widely utilized in promoting angiogenesis and compare their targets and functions. Lastly, since bolus injection of free proteins usually result in poor outcomes, we will focus on controlled release of proteins.
- Subjects :
- Angiogenesis Inducing Agents chemistry
Angiogenic Proteins biosynthesis
Angiogenic Proteins chemistry
Angiogenic Proteins genetics
Animals
Chemistry, Pharmaceutical
Delayed-Action Preparations
Drug Carriers
Drug Compounding
Gene Transfer Techniques
Genetic Therapy methods
Humans
Ischemia genetics
Ischemia metabolism
Ischemia physiopathology
Neovascularization, Physiologic genetics
Stem Cell Transplantation
Technology, Pharmaceutical methods
Angiogenesis Inducing Agents administration & dosage
Angiogenic Proteins administration & dosage
Drug Delivery Systems
Ischemia drug therapy
Neovascularization, Physiologic drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2041-5990
- Volume :
- 3
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Therapeutic delivery
- Publication Type :
- Academic Journal
- Accession number :
- 22838066
- Full Text :
- https://doi.org/10.4155/tde.12.50