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Synthesis from D-altrose of (5R,6R,7R,8S)-5,7-dihydroxy-8-hydroxymethylconidine and 2,4-dideoxy-2,4-imino-D-glucitol, azetidine analogues of swainsonine and 1,4-dideoxy-1,4-imino-D-mannitol.
- Source :
-
Organic letters [Org Lett] 2012 Aug 17; Vol. 14 (16), pp. 4174-7. Date of Electronic Publication: 2012 Jul 27. - Publication Year :
- 2012
-
Abstract
- Ring closure of a 3,5-di-O-triflate derived from D-altrose with benzylamine allowed the formation of both monocyclic and bicyclic azetidine analogues of swainsonine.
- Subjects :
- Azetidines chemistry
Cyclization
Imino Furanoses chemical synthesis
Imino Furanoses chemistry
Mannitol chemical synthesis
Mannitol chemistry
Mannosidases antagonists & inhibitors
Molecular Structure
Polymers chemistry
Sorbitol analogs & derivatives
Structure-Activity Relationship
Swainsonine chemistry
Azetidines chemical synthesis
Hexoses chemistry
Mannitol analogs & derivatives
Polymers chemical synthesis
Swainsonine analogs & derivatives
Swainsonine chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 14
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 22839435
- Full Text :
- https://doi.org/10.1021/ol301844n