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Stereotactic body radiation therapy for abdominal oligometastases: a biological and clinical review.
- Source :
-
Radiation oncology (London, England) [Radiat Oncol] 2012 Aug 01; Vol. 7, pp. 126. Date of Electronic Publication: 2012 Aug 01. - Publication Year :
- 2012
-
Abstract
- Advances in imaging and biological targeting have led to the development of stereotactic body radiation therapy (SBRT) as an alternative treatment of extracranial oligometastases. New radiobiological concepts, such as ceramide-induced endothelial apoptosis after hypofractionated high-dose SBRT, and the identification of patients with oligometastatic disease by microRNA expression may yet lead to further developments. Key factors in SBRT are delivery of a high dose per fraction, proper patient positioning, target localisation, and management of breathing-related motion. Our review addresses the radiation doses and schedules used to treat liver, abdominal lymph node (LN) and adrenal gland oligometastases and treatment outcomes. Reported local control (LC) rates for liver and abdominal LN oligometastases are high (median 2-year actuarial LC: 61 -100% for liver oligometastases; 4-year actuarial LC: 68% in a study of abdominal LN oligometastases). Early toxicity is low-to-moderate; late adverse effects are rare. SBRT of adrenal gland oligometastases shows promising results in the case of isolated lesions. In conclusion, properly conducted SBRT procedures are a safe and effective treatment option for abdominal oligometastases.
- Subjects :
- Clinical Trials as Topic statistics & numerical data
Dose Fractionation, Radiation
Dose-Response Relationship, Radiation
Humans
Liver Neoplasms secondary
Liver Neoplasms surgery
Lung Neoplasms secondary
Lung Neoplasms surgery
Lymph Nodes surgery
Neoplasms, Second Primary secondary
Neoplasms, Second Primary surgery
Abdominal Neoplasms secondary
Abdominal Neoplasms surgery
Carcinoma secondary
Carcinoma surgery
Radiosurgery methods
Subjects
Details
- Language :
- English
- ISSN :
- 1748-717X
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Radiation oncology (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 22852764
- Full Text :
- https://doi.org/10.1186/1748-717X-7-126