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Movement-related changes in local and long-range synchronization in Parkinson's disease revealed by simultaneous magnetoencephalography and intracranial recordings.
- Source :
-
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2012 Aug 01; Vol. 32 (31), pp. 10541-53. - Publication Year :
- 2012
-
Abstract
- Functional neurosurgery has afforded the opportunity to assess interactions between populations of neurons in the human cerebral cortex and basal ganglia in patients with Parkinson's disease (PD). Interactions occur over a wide range of frequencies, and the functional significance of those >30 Hz is particularly unclear. Do they improve movement, and, if so, in what way? We acquired simultaneously magnetoencephalography and direct recordings from the subthalamic nucleus (STN) in 17 PD patients. We examined the effect of synchronous and sequential finger movements and of the dopamine prodrug levodopa on induced power in the contralateral primary motor cortex (M1) and STN and on the coherence between the two structures. We observed discrete peaks in M1 and STN power at 60-90 Hz and at 300-400 Hz. All these power peaks increased with movement and levodopa treatment. Only STN activity at 60-90 Hz was coherent with activity in M1. Directionality analysis showed that STN gamma activity at 60-90 Hz tended to drive gamma activity in M1. The effects of levodopa on both local and distant synchronization at 60-90 Hz correlated with the degree of improvement in bradykinesia-rigidity as did local STN activity at 300-400 Hz. Despite this, there were no effects of movement type, nor interactions between movement type and levodopa in the STN, nor in the coherence between STN and M1. We conclude that synchronization at 60-90 Hz in the basal ganglia cortical network is prokinetic but likely through a modulatory effect rather than any involvement in explicit motor processing.
- Subjects :
- Adult
Analysis of Variance
Antiparkinson Agents pharmacology
Antiparkinson Agents therapeutic use
Cortical Synchronization drug effects
Deep Brain Stimulation
Electroencephalography
Female
Fingers physiopathology
Functional Laterality
Humans
Levodopa pharmacology
Levodopa therapeutic use
Magnetoencephalography
Male
Middle Aged
Motor Cortex drug effects
Motor Cortex physiopathology
Neurons drug effects
Parkinson Disease drug therapy
Psychomotor Performance
Spectrum Analysis
Statistics as Topic
Subthalamic Nucleus drug effects
Time Factors
Cortical Synchronization physiology
Movement physiology
Neurons physiology
Parkinson Disease pathology
Parkinson Disease physiopathology
Subthalamic Nucleus pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2401
- Volume :
- 32
- Issue :
- 31
- Database :
- MEDLINE
- Journal :
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 22855804
- Full Text :
- https://doi.org/10.1523/JNEUROSCI.0767-12.2012