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Acute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis-vulnerable T cells in HIV-1-infected infants.

Authors :
Slyker JA
Rowland-Jones SL
Dong T
Reilly M
Richardson B
Emery VC
Atzberger A
Mbori-Ngacha D
Lohman-Payne BL
John-Stewart GC
Source :
Journal of virology [J Virol] 2012 Oct; Vol. 86 (20), pp. 11373-9. Date of Electronic Publication: 2012 Aug 08.
Publication Year :
2012

Abstract

Cytomegalovirus (CMV) coinfection is associated with infant HIV-1 disease progression and mortality. In a cohort of Kenyan HIV-infected infants, the frequencies of activated (CD38(+) HLA-DR(+)) and apoptosis-vulnerable (CD95(+) Bcl-2(-)) CD4(+) and CD8(+) T cells increased substantially during acute CMV infection. The frequency of activated CD4(+) T cells was strongly associated with both concurrent CMV coinfection (P = 0.001) and HIV-1 viral load (P = 0.05). The frequency of apoptosis-vulnerable cells was also associated with CMV coinfection in the CD4 (P = 0.02) and CD8 (P < 0.001) T cell subsets. Similar observations were made in HIV-exposed uninfected infants. CMV-induced increases in T cell activation and apoptosis may contribute to the rapid disease progression in coinfected infants.

Details

Language :
English
ISSN :
1098-5514
Volume :
86
Issue :
20
Database :
MEDLINE
Journal :
Journal of virology
Publication Type :
Academic Journal
Accession number :
22875969
Full Text :
https://doi.org/10.1128/JVI.00790-12