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Placenta share discordance and umbilical artery Doppler change after antenatal betamethasone administration in monochorionic twins with selective intrauterine growth restriction: is there a link?
- Source :
-
Twin research and human genetics : the official journal of the International Society for Twin Studies [Twin Res Hum Genet] 2012 Oct; Vol. 15 (5), pp. 680-4. Date of Electronic Publication: 2012 Jul 03. - Publication Year :
- 2012
-
Abstract
- This study was designed to evaluate the degree of placenta share discordance in relation to the betamethasone-induced return of positive end-diastolic flow in monochorionic twin pregnancies with selective intrauterine growth restriction (sIUGR) and abnormal umbilical artery Doppler. Monochorionic twins with sIUGR was defined as one twin having an estimated fetal weight below the 10th percentile combined with an estimated fetal weight discordance >25%. The umbilical artery Doppler directly prior to (D0) and 24 hours (D1) and 48 hours (D2) after the first dose of betamethasone administration was recorded. The estimated individual placental weight in monochorionic twins was obtained by cutting the placenta along the vascular equator into two territories; the placenta share discordance was calculated as [(estimated individual placental weight of appropriated for gestational age twin- estimated individual placental weight of growth restricted twin)/estimated individual placental weight of appropriated for gestational age twin] × 100%. Six (23.1%) of the 26 included cases achieved betamethasone-induced return of positive umbilical artery end-diastolic flow. The difference of placenta share discordance and birth weight discordance were not significantly different between twins with and without betamethasone-induced return of positive umbilical artery end-diastolic flow. Thus, according to our study results, it was proposed that although the placenta share discordance correlated with the abnormal umbilical artery Doppler in the IUGR fetus in monochorionic twin, the betamethasone-induced return of positive umbilical artery end-diastolic flow, however, did not reveal the similar relationship with the severity of placenta share discordance.
- Subjects :
- Betamethasone therapeutic use
Birth Weight
Female
Fetal Growth Retardation diagnostic imaging
Fetal Weight
Humans
Infant, Newborn
Placenta diagnostic imaging
Placenta drug effects
Pregnancy
Pregnancy Complications, Hematologic diagnostic imaging
Pregnancy Complications, Hematologic drug therapy
Pregnancy, Twin drug effects
Prospective Studies
Twins, Monozygotic
Ultrasonography, Doppler
Ultrasonography, Prenatal
Umbilical Arteries drug effects
Betamethasone administration & dosage
Fetal Growth Retardation drug therapy
Placenta blood supply
Umbilical Arteries diagnostic imaging
Umbilical Arteries physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1832-4274
- Volume :
- 15
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Twin research and human genetics : the official journal of the International Society for Twin Studies
- Publication Type :
- Academic Journal
- Accession number :
- 22877960
- Full Text :
- https://doi.org/10.1017/thg.2012.39