Back to Search
Start Over
Priming effect of aspirin for tumor cells to augment cytotoxic action of cisplatin against tumor cells: implication of altered constitution of tumor microenvironment, expression of cell cycle, apoptosis, and survival regulatory molecules.
- Source :
-
Molecular and cellular biochemistry [Mol Cell Biochem] 2012 Dec; Vol. 371 (1-2), pp. 43-54. Date of Electronic Publication: 2012 Aug 15. - Publication Year :
- 2012
-
Abstract
- The present study was conducted to investigate if anti-inflammatory drug aspirin could alter the cytotoxic action of cisplatin on tumor cells. Using a transplantable T cell lymphoma in a murine model, we demonstrate that exposure to aspirin exerts a priming action on tumor cells, rendering them susceptible to induction of cell death by cisplatin with consequences on retardation of tumor progression. The priming action of aspirin on tumor cells was found to be dependent on an altered constitution of tumor microenvironment with respect to decline of acidosis and modulation in the expression of cell cycle and survival regulatory molecules like cyclin B1, cyclin D, bcl-2, bcl-xL, p53, and cytokines: IL-4, IL-10, IFN- γ & VEGF. The study also discusses possible mechanisms underlying augmentary action of aspirin on cisplatin-mediated tumor cells killing. This is the first report showing that pre-exposure of tumor cells to aspirin lowers the concentration of cisplatin to exert its cytotoxic action. The finding of this study will help in designing novel antitumor protocols with reduced dose of cisplatin.
- Subjects :
- Animals
Cell Death
Cell Survival
Cyclins metabolism
Cytokines metabolism
Drug Synergism
Interleukin-10 metabolism
Interleukin-4 metabolism
Male
Mice
Mice, Inbred BALB C
Tumor Cells, Cultured
Tumor Microenvironment
Antineoplastic Agents pharmacology
Apoptosis
Aspirin pharmacology
Cell Cycle drug effects
Cisplatin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4919
- Volume :
- 371
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Molecular and cellular biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 22893064
- Full Text :
- https://doi.org/10.1007/s11010-012-1421-9