Back to Search
Start Over
Innate immunity and the regulation and mobilization of keratinocyte stem cells: are the old players playing a new game?
- Source :
-
Experimental dermatology [Exp Dermatol] 2012 Sep; Vol. 21 (9), pp. 660-4. - Publication Year :
- 2012
-
Abstract
- The skin provides an anatomical barrier to physical, chemical and biological agents. Hence, it is not surprising that it has well-developed innate immunity. What we find surprising is that the CD49f(+) /CD34(+) hair follicle stem cells should have an enriched expression profile of so many genes involved in innate immunity. Do these stem cells require extra protection from environmental insults? Or, could there be a new role for these genes? To probe these questions, we first summarize the roles of some key players in epidermal innate immunity. We next focus on their expression in CD49f(+) /CD34(+) hair follicle stem cells. Then, we consider recent data suggesting a new role for these 'old players' in the regulation and mobilization of haematopoietic and mesenchymal stem cells. Finally, we hypothesize that the 'old players' in these hair follicle stem cells may be playing a 'new game'.<br /> (© 2012 John Wiley & Sons A/S.)
- Subjects :
- Antigens, CD34 metabolism
Cytokines immunology
Cytokines metabolism
Endotoxins immunology
Hair Follicle metabolism
Hematopoietic Stem Cells immunology
Humans
Immunity, Innate immunology
Integrin alpha6 metabolism
Keratinocytes metabolism
Mesenchymal Stem Cells immunology
Signal Transduction immunology
Stem Cells metabolism
Toll-Like Receptors genetics
Toll-Like Receptors metabolism
Hair Follicle immunology
Immunity, Innate genetics
Keratinocytes immunology
Stem Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0625
- Volume :
- 21
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Experimental dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 22897573
- Full Text :
- https://doi.org/10.1111/j.1600-0625.2012.01566.x