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CD4 T follicular helper cell dynamics during SIV infection.
- Source :
-
The Journal of clinical investigation [J Clin Invest] 2012 Sep; Vol. 122 (9), pp. 3281-94. Date of Electronic Publication: 2012 Aug 27. - Publication Year :
- 2012
-
Abstract
- CD4 T follicular helper (TFH) cells interact with and stimulate the generation of antigen-specific B cells. TFH cell interaction with B cells correlates with production of SIV-specific immunoglobulins. However, the fate of TFH cells and their participation in SIV-induced antibody production is not well understood. We investigated the phenotype, function, location, and molecular signature of TFH cells in rhesus macaques. Similar to their human counterparts, TFH cells in rhesus macaques represented a heterogeneous population with respect to cytokine function. In a highly differentiated subpopulation of TFH cells, characterized by CD150lo expression, production of Th1 cytokines was compromised while IL-4 production was augmented, and cells exhibited decreased survival, cycling, and trafficking capacity. TFH cells exhibited a distinct gene profile that was markedly altered by SIV infection. TFH cells were infected by SIV; yet, in some animals, these cells actually accumulated during chronic SIV infection. Generalized immune activation and increased IL-6 production helped drive TFH differentiation during SIV infection. Accumulation of TFH cells was associated with increased frequency of activated germinal center B cells and SIV-specific antibodies. Therefore, chronic SIV does not disturb the ability of TFH cells to help B cell maturation and production of SIV-specific immunoglobulins.
- Subjects :
- Animals
Antibodies, Viral blood
B-Lymphocytes immunology
B-Lymphocytes metabolism
CD4 Antigens metabolism
Cell Death
Cell Proliferation
Cytokines metabolism
Gene Expression
Germinal Center pathology
Germinal Center virology
Host-Pathogen Interactions
Lymph Nodes metabolism
Lymph Nodes pathology
Lymph Nodes virology
Macaca mulatta
Oligonucleotide Array Sequence Analysis
Proto-Oncogene Proteins c-maf genetics
Proto-Oncogene Proteins c-maf metabolism
Receptors, Lysosphingolipid genetics
Receptors, Lysosphingolipid metabolism
Simian Acquired Immunodeficiency Syndrome blood
Simian Acquired Immunodeficiency Syndrome pathology
Simian Immunodeficiency Virus physiology
T-Box Domain Proteins genetics
T-Box Domain Proteins metabolism
T-Lymphocytes, Helper-Inducer immunology
Transcription Factors genetics
Transcription Factors metabolism
Transcriptome
Simian Acquired Immunodeficiency Syndrome immunology
Simian Immunodeficiency Virus immunology
T-Lymphocytes, Helper-Inducer metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1558-8238
- Volume :
- 122
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Journal of clinical investigation
- Publication Type :
- Academic Journal
- Accession number :
- 22922258
- Full Text :
- https://doi.org/10.1172/JCI63039