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Pathogenesis of Parkinson's disease.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2013 Jan; Vol. 28 (1), pp. 24-30. Date of Electronic Publication: 2012 Aug 23. - Publication Year :
- 2013
-
Abstract
- Parkinson's disease is a common adult-onset neurodegenerative disorder whose pathogenesis remains essentially unknown. Currently, it is believed that the neurodegenerative process in Parkinson's disease is a combination of both cell-autonomous and non-cell-autonomous mechanisms. Proposed cell-autonomous mechanisms include alterations in mitochondrial bioenergetics, dysregulation of calcium homeostasis, and impaired turnover of mitochondria. As for the proposed non-cell-autonomous mechanisms, they involve prion-like behavior of misfolded proteins and neuroinflammation. This suggests that cell death in Parkinson's disease is caused by a multifactorial cascade of pathogenic events and argues that effective neuroprotective therapy for Parkinson's disease may have to rely on multiple drug interventions.<br /> (Copyright © 2013 Movement Disorders Society.)
Details
- Language :
- English
- ISSN :
- 1531-8257
- Volume :
- 28
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 22927094
- Full Text :
- https://doi.org/10.1002/mds.25032