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Prognostic value of serum cystatin C and N-terminal pro b-type natriuretic peptide in patients with acute heart failure.
- Source :
-
European journal of internal medicine [Eur J Intern Med] 2012 Oct; Vol. 23 (7), pp. 599-603. Date of Electronic Publication: 2012 Jun 22. - Publication Year :
- 2012
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Abstract
- Background: Cystatin C (CysC) is a good prognostic marker in heart failure. However, there is not much information of CysC combined with other biomarkers in acute heart failure (AHF).<br />Aim: To assess prognostic value of CysC and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients hospitalized for AHF with no apparent deterioration of renal function.<br />Design: Prospective, multicenter, observational study.<br />Methods: CysC and NTpro-BNP were measured in patients consecutively admitted with a diagnosis of AHF. Patients with, NTpro-BNP concentration above 900 pg/mL and serum creatinine below 1.3mg/dL, were included for statistical analysis. End-point of the study was all-cause mortality during a 12-month follow-up.<br />Results: 526 patients with AHF and NTpro-BNP concentration above 900 pg/mL were included in the study. From this group, 367 patients (69.8%) had serum creatinine below 1.3mg/dL. Receiver operating characteristic (ROC) curves were used to determine the best cut-off value for CysC. Patients with a concentration of CsyC above 1.25mg/dL had a 37.8% mortality rate, vs. 13.6% for those below cut-off (p<0.001). After Cox proportional hazard model, age, CysC, low total cholesterol and HF with preserved ejection fraction remained significantly associated with all-cause mortality during one-year follow-up.<br />Conclusions: In AHF and normal or slightly impaired renal function, performance of CysC may be superior to NT-proBNP. Hence, CysC may be the preferred biomarker in the assessment of patients with AHF and slightly impaired renal function.<br /> (Copyright © 2012 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Biomarkers blood
Cohort Studies
Creatinine blood
Female
Heart Failure diagnosis
Heart Failure mortality
Humans
Male
Prognosis
Proportional Hazards Models
Prospective Studies
ROC Curve
Cystatin C blood
Heart Failure blood
Natriuretic Peptide, Brain blood
Peptide Fragments blood
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0828
- Volume :
- 23
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- European journal of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 22939803
- Full Text :
- https://doi.org/10.1016/j.ejim.2012.06.002